LITAF

LITAF
Identifiers
Aliases	LITAF, PIG7, SIMPLE, TP53I7, lipopolysaccharide induced TNF factor
External IDs	OMIM: 603795; MGI: 1929512; HomoloGene: 37974; GeneCards: LITAF; OMA:LITAF - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	11,636,381 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	10,884,021 bp
RNA expression pattern
	Top expressed in
	blood; ; palpebral conjunctiva; ; periodontal fiber; ; visceral pleura; ; mucosa of urinary bladder; ; appendix; ; tibia; ; granulocyte; ; canal of the cervix; ; gallbladder;
	Top expressed in
	granulocyte; ; endothelial cell of lymphatic vessel; ; stroma of bone marrow; ; blood; ; decidua; ; vestibular sensory epithelium; ; left colon; ; gastrula; ; vestibular membrane of cochlear duct; ; skin of external ear;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; protein binding; WW domain binding; zinc ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA binding; metal ion binding;
Cellular component	membrane; nucleoplasm; lysosomal membrane; lysosome; cytosol; cytoplasmic side of plasma membrane; cytoplasmic side of early endosome membrane; cytoplasmic side of late endosome membrane; cytoplasmic side of lysosomal membrane; Golgi membrane; nucleus; cytoplasm; endosome; Golgi apparatus; plasma membrane; endosome membrane; early endosome membrane; late endosome membrane; intracellular membrane-bounded organelle; integral component of membrane;
Biological process	regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; ageing; transcription, DNA-templated; regulation of cytokine production; response to lipopolysaccharide; positive regulation of I-kappaB kinase/NF-kappaB signaling; cellular response to lipopolysaccharide; signal transduction; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	9516
	56722
	ENSG00000189067
	ENSMUSG00000022500
	Q99732
	Q9JLJ0
	NM_001136472; NM_001136473; NM_004862
	NM_019980
	NP_001129944; NP_001129945; NP_004853
	NP_064364
	Wikidata
View/Edit Human	View/Edit Mouse

Lipopolysaccharide-induced tumor necrosis factor-alpha factor is a protein that in humans is encoded by the LITAF gene.

It is associated with Charcot–Marie–Tooth disease 1C.