LLGL1

LLGL1
Identifiers
Aliases	LLGL1, DLG4, HUGL, HUGL-1, HUGL1, LLGL, Lgl1, Mgl1, scribble cell polarity complex component, LLGL scribble cell polarity complex component 1
External IDs	OMIM: 600966; MGI: 102682; HomoloGene: 31220; GeneCards: LLGL1; OMA:LLGL1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	18,244,875 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	60,605,012 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; ventricular zone; ; ganglionic eminence; ; substantia nigra; ; hippocampus proper; ; temporal lobe; ; Amygdala; ; putamen; ; stromal cell of endometrium; ; caudate nucleus;
	Top expressed in
	medial ganglionic eminence; ; ventricular zone; ; Rostral migratory stream; ; CA3 field; ; primitive streak; ; entorhinal cortex; ; somite; ; perirhinal cortex; ; mandibular prominence; ; lactiferous gland;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity; structural molecule activity; protein binding; syntaxin binding; protein kinase binding; myosin II binding;
Cellular component	cytoplasm; endosome; Golgi apparatus; cell projection; trans-Golgi network membrane; early endosome membrane; membrane; Golgi membrane; plasma membrane; Golgi cis cisterna; axon; cortical actin cytoskeleton; cytoskeleton;
Biological process	axonogenesis; regulation of exocytosis; Golgi to plasma membrane transport; cortical actin cytoskeleton organization; exocytosis; regulation of protein secretion; positive regulation of GTPase activity; protein-containing complex assembly; regulation of establishment or maintenance of cell polarity; establishment of spindle orientation; regulation of Notch signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3996
	16897
	ENSG00000284137; ENSG00000131899
	ENSMUSG00000020536
	Q15334
	Q80Y17
	NM_004140
	NM_001159404; NM_001159405; NM_008502; NM_001378836; NM_001378837
	NP_004131
	NP_001152876; NP_001152877; NP_032528; NP_001365765; NP_001365766
	Wikidata
View/Edit Human	View/Edit Mouse

Lethal(2) giant larvae protein homolog 1 is a protein that in humans is encoded by the LLGL1 gene.

This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17.