Lamin B1

LMNB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KPW, 3JT0, 3TYY, 3UMN
Identifiers
Aliases	LMNB1, ADLD, LMN, LMN2, LMNB, lamin B1, MCPH26
External IDs	OMIM: 150340; MGI: 96795; HomoloGene: 55912; GeneCards: LMNB1; OMA:LMNB1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	126,837,020 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	56,886,496 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; monocyte; ; rectum; ; appendix; ; mucosa of transverse colon; ; bone marrow; ; blood; ; bone marrow cells; ; buccal mucosa cell;
	Top expressed in
	ventricular zone; ; granulocyte; ; tail of embryo; ; epiblast; ; abdominal wall; ; genital tubercle; ; thymus; ; yolk sac; ; ganglionic eminence; ; medial ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phospholipase binding; structural molecule activity; protein binding; double-stranded DNA binding; sequence-specific double-stranded DNA binding;
Cellular component	nuclear matrix; nuclear inner membrane; nuclear membrane; membrane; intermediate filament; lamin filament; nucleoplasm; nucleus; nuclear envelope;
Biological process	interleukin-12-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4001
	16906
	ENSG00000113368
	ENSMUSG00000024590
	P20700
	P14733
	NM_001198557; NM_005573
	NM_010721
	NP_001185486; NP_005564
	NP_034851
	Wikidata
View/Edit Human	View/Edit Mouse

Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene.

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure, and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Lamin B, along with heterochromatin, is anchored to the inner surface of the nuclear membrane by the lamin B receptor.