LMO3

LMO3
Identifiers
Aliases	LMO3, RBTN3, RBTNL2, RHOM3, Rhom-3, LIM domain only 3
External IDs	OMIM: 180386; MGI: 102810; HomoloGene: 136507; GeneCards: LMO3; OMA:LMO3 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	16,610,594 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	138,558,966 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 46; ; Brodmann area 23; ; orbitofrontal cortex; ; superior frontal gyrus; ; entorhinal cortex; ; endothelial cell; ; postcentral gyrus; ; optic nerve; ; nucleus accumbens;
	Top expressed in
	piriform cortex; ; Region I of hippocampus proper; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; Amygdala; ; hippocampus proper; ; lumbar subsegment of spinal cord; ; dorsal striatum; ; primary visual cortex; ; anterior amygdaloid area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding;
Cellular component	cytoplasm;
Biological process	negative regulation of ERK1 and ERK2 cascade; regulation of transcription, DNA-templated; positive regulation of fat cell differentiation; positive regulation of glucocorticoid receptor signaling pathway; transcription, DNA-templated; positive regulation of peroxisome proliferator activated receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	55885
	109593
	ENSG00000048540
	ENSMUSG00000030226
	Q8TAP4
	Q8BZL8
NM_001001395; NM_001243609; NM_001243610; NM_001243611; NM_001243612;
	NM_001243613; NM_018640
	NM_207222; NM_001356305; NM_001356306; NM_001356307
NP_001001395; NP_001230538; NP_001230539; NP_001230540; NP_001230541;
	NP_001230542; NP_061110
	NP_997105; NP_001343234; NP_001343235; NP_001343236
	Wikidata
View/Edit Human	View/Edit Mouse

LIM domain only protein 3 is a transcription co-factor, which in humans is encoded by the LMO3 gene. LMO3 interacts with the tumor suppressor p53 and regulates its function. LMO3 is considered to be an oncogene in Neuroblastoma.