Lysyl oxidase

LOX
Identifiers
Aliases	LOX, entrez:4015, lysyl oxidase, AAT10, Lysyl oxidase
External IDs	OMIM: 153455; MGI: 96817; HomoloGene: 1741; GeneCards: LOX; OMA:LOX - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	122,078,413 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	52,662,939 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; Achilles tendon; ; tibia; ; skin of hip; ; periodontal fiber; ; cartilage tissue; ; pericardium; ; ventricular zone; ; skin of arm; ; skin of thigh;
	Top expressed in
	stroma of bone marrow; ; umbilical cord; ; calvaria; ; body of femur; ; left lung lobe; ; molar; ; efferent ductule; ; dermis; ; ankle; ; ascending aorta;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor; metal ion binding; protein binding; oxidoreductase activity; copper ion binding; protein-lysine 6-oxidase activity;
Cellular component	collagen; nucleus; extracellular region; extracellular space; extracellular matrix;
Biological process	collagen fibril organization; lung development; response to steroid hormone; wound healing; aorta development; heart development; blood vessel development; response to hormone; elastic fiber assembly; blood vessel morphogenesis; peptidyl-lysine oxidation; osteoblast differentiation; regulation of protein phosphorylation; regulation of gene expression; regulation of striated muscle tissue development; regulation of transforming growth factor beta receptor signaling pathway; extracellular matrix organization; bone mineralization; platelet-derived growth factor receptor-beta signaling pathway; ascending aorta development; descending aorta development; regulation of apoptotic process; protein kinase B signaling; regulation of megakaryocyte differentiation; muscle cell cellular homeostasis; cell chemotaxis; connective tissue development; cellular response to organic substance; DNA biosynthetic process; regulation of receptor binding; regulation of bone development; cellular response to chemokine; regulation of platelet-derived growth factor receptor-beta signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4015
	16948
	ENSG00000113083
	ENSMUSG00000024529
	P28300
	P28301
	NM_002317; NM_001178102; NM_001317073
	NM_010728; NM_001286181; NM_001286182
	NP_001171573; NP_001304002; NP_002308
	NP_001273110; NP_001273111; NP_034858
	Wikidata
View/Edit Human	View/Edit Mouse

Lysyl oxidase (LOX), also known as protein-lysine 6-oxidase, is an enzyme that, in humans, is encoded by the LOX gene. It catalyzes the conversion of lysine residues into its aldehyde derivative allysine. Allysine form cross-links in extracellular matrix proteins. Inhibition of lysyl oxidase can cause osteolathyrism, but, at the same time, its upregulation by tumor cells may promote metastasis of the existing tumor, causing it to become malignant and cancerous.