LPAR6

LPAR6
Identifiers
Aliases	LPAR6, ARWH1, HYPT8, LAH3, P2RY5, P2Y5, lysophosphatidic acid receptor 6, LPA-6
External IDs	OMIM: 609239; MGI: 1914418; HomoloGene: 55925; GeneCards: LPAR6; OMA:LPAR6 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	48,444,704 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	73,480,734 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; monocyte; ; skin of hip; ; minor salivary glands; ; oral cavity; ; vagina; ; granulocyte; ; olfactory zone of nasal mucosa; ; Achilles tendon; ; gallbladder;
	Top expressed in
	hand; ; hair follicle; ; brown adipose tissue; ; medullary collecting duct; ; mammary gland; ; otolith organ; ; utricle; ; skin of abdomen; ; mandibular prominence; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; lysophosphatidic acid receptor activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane; intracellular membrane-bounded organelle;
Biological process	signal transduction; positive regulation of Rho protein signal transduction; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; G protein-coupled receptor signaling pathway; blastocyst hatching;
	Sources:Amigo / QuickGO
Orthologs
	10161
	67168
	ENSG00000139679
	ENSMUSG00000033446
	P43657
	Q8BMC0
	NM_005767; NM_001162497; NM_001162498; NM_001377316; NM_001377317
	NM_175116
	NP_001155969; NP_001155970; NP_005758; NP_001364245; NP_001364246
	NP_780325
	Wikidata
View/Edit Human	View/Edit Mouse

Lysophosphatidic acid receptor 6, also known as LPA₆, P2RY5 and GPR87, is a protein that in humans is encoded by the LPAR6 gene. LPA₆ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation.