Latrophilin 1

ADGRL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JX9, 2JXA
Identifiers
Aliases	ADGRL1, CIRL1, CL1, LEC2, LPHN1, adhesion G protein-coupled receptor L1
External IDs	OMIM: 616416; MGI: 1929461; HomoloGene: 8951; GeneCards: ADGRL1; OMA:ADGRL1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	14,206,187 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	83,941,954 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; superior frontal gyrus; ; primary visual cortex; ; right frontal lobe; ; prefrontal cortex; ; dorsolateral prefrontal cortex; ; anterior cingulate cortex; ; Brodmann area 9; ; hippocampus proper; ; temporal lobe;
	Top expressed in
	CA3 field; ; primary visual cortex; ; entorhinal cortex; ; perirhinal cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; prefrontal cortex; ; nucleus accumbens; ; primary motor cortex; ; cerebellar cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; protein binding; transmembrane signaling receptor activity; cell adhesion molecule binding; carbohydrate binding; latrotoxin receptor activity;
Cellular component	integral component of membrane; cell projection; membrane; growth cone; plasma membrane; synapse; cell junction; axon; neuron projection; presynaptic membrane; intracellular anatomical structure; integral component of plasma membrane; postsynaptic density;
Biological process	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; calcium-mediated signaling using intracellular calcium source; signal transduction; positive regulation of synapse assembly; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; positive regulation of synapse maturation; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	22859
	330814
	ENSG00000072071; ENSG00000288324
	ENSMUSG00000013033
	O94910
	Q80TR1
	NM_001008701; NM_014921
	NM_181039
	NP_001008701; NP_055736
	NP_851382
	Wikidata
View/Edit Human	View/Edit Mouse

Latrophilin 1 is a protein that in humans is encoded by the ADGRL1 gene. It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.