LPXN

LPXN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X3H, 4XEF, 4XEK, 4XEV
Identifiers
Aliases	LPXN, LDPL, leupaxin
External IDs	OMIM: 605390; MGI: 2147677; HomoloGene: 3536; GeneCards: LPXN; OMA:LPXN - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	58,578,220 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	12,811,171 bp
RNA expression pattern
	Top expressed in
	thymus; ; granulocyte; ; mononuclear cell; ; monocyte; ; appendix; ; lymph node; ; blood; ; spleen; ; mucosa of ileum; ; epithelium of nasopharynx;
	Top expressed in
	mesenteric lymph nodes; ; spermatocyte; ; stroma of bone marrow; ; spleen; ; thymus; ; seminiferous tubule; ; blood; ; spermatid; ; medulla of thymus; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; transcription coregulator activity; metal ion binding;
Cellular component	cytoplasm; perinuclear region of cytoplasm; podosome; cell junction; plasma membrane; cell projection; nucleus; focal adhesion; membrane; cytosol; nuclear speck;
Biological process	negative regulation of B cell receptor signaling pathway; negative regulation of cell adhesion; cell adhesion; regulation of cell adhesion mediated by integrin; regulation of transcription, DNA-templated; transcription, DNA-templated; signal transduction; protein-containing complex assembly; regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	9404
	107321
	ENSG00000110031
	ENSMUSG00000024696
	O60711
	Q99N69
	NM_001143995; NM_001307951; NM_004811
	NM_134152; NM_001361971
	NP_001137467; NP_001294880; NP_004802
	NP_598913; NP_001348900
	Wikidata
View/Edit Human	View/Edit Mouse

Leupaxin is a protein that in humans is encoded by the LPXN gene.

The product encoded by this gene is preferentially expressed in hematopoietic cells and is most homologous to the focal adhesion protein, paxillin. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by tyrosine kinase activity.