Ligand-dependent nuclear receptor-interacting factor 1

LRIF1
Identifiers
Aliases	LRIF1, C1orf103, RIF1, ligand dependent nuclear receptor interacting factor 1, HBiX1, FSHD3
External IDs	OMIM: 615354; MGI: 2445214; HomoloGene: 10160; GeneCards: LRIF1; OMA:LRIF1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	110,963,965 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	106,643,893 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; gonad; ; testicle; ; Epithelium of choroid plexus; ; sperm; ; right testis; ; Skeletal muscle tissue of rectus abdominis; ; left testis; ; muscle of thigh; ; corpus epididymis;
	Top expressed in
	spermatid; ; genital tubercle; ; spermatocyte; ; olfactory epithelium; ; granulocyte; ; seminiferous tubule; ; pineal gland; ; tail of embryo; ; superior cervical ganglion; ; spleen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; retinoic acid receptor binding;
Cellular component	nuclear matrix; nucleus; microtubule organizing center; Barr body; chromosome;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; dosage compensation by inactivation of X chromosome;
	Sources:Amigo / QuickGO
Orthologs
	55791
	321000
	ENSG00000121931
	ENSMUSG00000056260
	Q5T3J3
	Q8CDD9
	NM_001006945; NM_018372
	NM_001039478; NM_001039488; NM_001286685; NM_028081; NM_177309
	NP_001006946; NP_060842
	NP_001034567; NP_001034577; NP_001273614; NP_082357
	Wikidata
View/Edit Human	View/Edit Mouse

Ligand-dependent nuclear receptor-interacting factor 1 (LRIF1) also known as receptor-interacting factor 1 (RIF1) is a protein that in humans is encoded by the LRIF1 gene.

LRIF1 has been shown to interact with SMCHD1 protein, mutation of which causes facioscapulohumeral muscular dystrophy type 2 (FSHD2). Mutation of LRIF1 itself has also been implicated in FSHD2.