LRP2

LRP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2M0P
Identifiers
Aliases	LRP2, DBS, GP330, LDL receptor related protein 2, LRP-2
External IDs	OMIM: 600073; MGI: 95794; HomoloGene: 20952; GeneCards: LRP2; OMA:LRP2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	169,362,534 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	69,416,409 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; human kidney; ; buccal mucosa cell; ; kidney tubule; ; inferior ganglion of vagus nerve; ; thyroid gland; ; retinal pigment epithelium; ; germinal epithelium; ; left lobe of thyroid gland; ; right lobe of thyroid gland;
	Top expressed in
	vestibular membrane of cochlear duct; ; human kidney; ; stria vascularis; ; right kidney; ; yolk sac; ; efferent ductule; ; olfactory epithelium; ; vestibular sensory epithelium; ; epiblast; ; glomerulus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; SH3 domain binding; metal ion binding; protein binding; low-density lipoprotein particle receptor activity; chaperone binding;
Cellular component	integral component of membrane; endosome; Golgi apparatus; membrane; receptor complex; plasma membrane; endocytic vesicle; apical part of cell; brush border membrane; lysosomal membrane; apical plasma membrane; endoplasmic reticulum; brush border; clathrin-coated pit; lysosome; extracellular exosome; clathrin-coated vesicle membrane; external side of plasma membrane; axon; dendrite; endosome lumen; cell projection;
Biological process	endocytosis; ventricular septum development; vitamin D metabolic process; lipid metabolism; receptor-mediated endocytosis; coronary vasculature development; retinoid metabolic process; aorta development; heart development; forebrain development; cell population proliferation; vitamin metabolic process; lipoprotein transport; membrane organization; neural tube closure; secondary heart field specification; outflow tract septum morphogenesis; ventricular compact myocardium morphogenesis; nervous system development; hearing; male gonad development; metal ion transport; negative regulation of BMP signaling pathway; positive regulation of neurogenesis; vagina development; coronary artery morphogenesis; pulmonary artery morphogenesis; positive regulation of oligodendrocyte progenitor proliferation; neuron projection arborization; folate import across plasma membrane; positive regulation of lysosomal protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	4036
	14725
	ENSG00000081479
	ENSMUSG00000027070
	P98164
	A2ARV4
	NM_004525
	NM_001081088
	NP_004516
	NP_001074557
	Wikidata
View/Edit Human	View/Edit Mouse

Low density lipoprotein receptor-related protein 2 also known as LRP-2 or megalin is a protein which in humans is encoded by the LRP2 gene.