Low-density lipoprotein receptor-related protein 4

LRP4
Identifiers
Aliases	LRP4, CLSS, LRP-4, LRP10, MEGF7, SOST2, CMS17, Low density lipoprotein receptor-related protein 4, LDL receptor related protein 4
External IDs	OMIM: 604270; MGI: 2442252; HomoloGene: 17964; GeneCards: LRP4; OMA:LRP4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	46,918,642 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	91,344,124 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; dorsal motor nucleus of vagus nerve; ; internal globus pallidus; ; putamen; ; caudate nucleus; ; skin of leg; ; skin of abdomen; ; inferior olivary nucleus; ; nucleus accumbens; ; Amygdala;
	Top expressed in
	Bowman's capsule; ; body of femur; ; ventricular zone; ; tail of embryo; ; left lung; ; spermatogonium; ; lip; ; right lung lobe; ; left lung lobe; ; skin of external ear;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; apolipoprotein binding; protein homodimerization activity; scaffold protein binding; receptor tyrosine kinase binding; protein binding; Wnt-protein binding; Wnt-activated receptor activity;
Cellular component	integral component of membrane; synaptic membrane; postsynaptic density; membrane; neuromuscular junction; cell surface; soma; flotillin complex; dendrite; receptor complex; plasma membrane; plasma membrane raft;
Biological process	animal organ development; hair follicle development; regulation of protein phosphorylation; protein localization; proximal/distal pattern formation; cell differentiation; protein heterotetramerization; endocytosis; dendrite morphogenesis; kidney development; anatomical structure development; synaptic assembly at neuromuscular junction; regulation of canonical Wnt signaling pathway; negative regulation of Wnt signaling pathway; synapse organization; embryonic digit morphogenesis; Wnt signaling pathway; receptor clustering; BMP signaling pathway; presynaptic membrane assembly; limb development; positive regulation of presynaptic membrane organization; negative regulation of ossification; multicellular organism development; odontogenesis of dentin-containing tooth; positive regulation of skeletal muscle acetylcholine-gated channel clustering; negative regulation of axonogenesis; postsynaptic membrane assembly; embryonic limb morphogenesis; skeletal muscle acetylcholine-gated channel clustering; positive regulation of peptidyl-tyrosine phosphorylation; dorsal/ventral pattern formation; negative regulation of canonical Wnt signaling pathway; Wnt signaling pathway involved in dorsal/ventral axis specification; amyloid-beta clearance by cellular catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	4038
	228357
	ENSG00000134569
	ENSMUSG00000027253
	O75096
	Q8VI56
	NM_002334
	NM_001145857; NM_172668
	NP_002325
	NP_001139329; NP_766256
	Wikidata
View/Edit Human	View/Edit Mouse

Low-density lipoprotein receptor-related protein 4 (LRP-4), also known as multiple epidermal growth factor-like domains 7 (MEGF7), is a protein that in humans is encoded by the LRP4 gene. LRP-4 is a member of the Lipoprotein receptor-related protein family and may be a regulator of Wnt signaling.