Low-density lipoprotein receptor-related protein 8

LRP8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3A7Q
Identifiers
Aliases	LRP8, APOER2, HSZ75190, LRP-8, MCI1, low density lipoprotein receptor-related protein 8, LDL receptor related protein 8
External IDs	OMIM: 602600; MGI: 1340044; HomoloGene: 31250; GeneCards: LRP8; OMA:LRP8 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	53,328,469 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	107,876,840 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; retinal pigment epithelium; ; ventricular zone; ; right testis; ; left testis; ; right lobe of thyroid gland; ; Pons; ; left lobe of thyroid gland; ; lateral nuclear group of thalamus; ; Brodmann area 46;
	Top expressed in
	ventricular zone; ; Rostral migratory stream; ; ganglionic eminence; ; habenula; ; neural layer of retina; ; olfactory bulb; ; tail of embryo; ; cerebellar cortex; ; primary visual cortex; ; superior frontal gyrus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	reelin receptor activity; calcium ion binding; apolipoprotein binding; protein binding; kinesin binding; high-density lipoprotein particle binding; very-low-density lipoprotein particle receptor activity; transmembrane signaling receptor activity; low-density lipoprotein particle receptor activity;
Cellular component	integral component of membrane; membrane; postsynaptic density; receptor complex; plasma membrane; microtubule associated complex; extracellular region; axon; soma; dendrite; caveola;
Biological process	endocytosis; ammon gyrus development; lipid metabolism; cytokine-mediated signaling pathway; cellular response to growth factor stimulus; positive regulation of protein tyrosine kinase activity; modulation of chemical synaptic transmission; negative regulation of transcription by RNA polymerase II; positive regulation of dendrite development; cellular response to cholesterol; proteolysis; retinoid metabolic process; reelin-mediated signaling pathway; positive regulation of CREB transcription factor activity; cerebral cortex development; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of dendritic spine morphogenesis; signal transduction; receptor-mediated endocytosis; regulation of apoptotic process; regulation of innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	7804
	16975
	ENSG00000157193
	ENSMUSG00000028613
	Q14114
	Q924X6
	NM_001018054; NM_004631; NM_017522; NM_033300
NM_001080926; NM_053073; NM_001369051; NM_001369052; NM_001369053;
	NM_001369054
	NP_001018064; NP_004622; NP_059992; NP_150643
NP_001074395; NP_001355980; NP_001355981; NP_001355982; NP_001355983;
	NP_444303
	Wikidata
View/Edit Human	View/Edit Mouse

Low-density lipoprotein receptor-related protein 8 (LRP8), also known as apolipoprotein E receptor 2 (ApoER2), is a protein that in humans is encoded by the LRP8 gene. ApoER2 is a cell surface receptor that is part of the low-density lipoprotein receptor family. These receptors function in signal transduction and endocytosis of specific ligands. Through interactions with one of its ligands, reelin, ApoER2 plays an important role in embryonic neuronal migration and postnatal long-term potentiation. Another LDL family receptor, VLDLR, also interacts with reelin, and together these two receptors influence brain development and function. Decreased expression of ApoER2 is associated with certain neurological diseases.