LRRC4

LRRC4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DL9, 3ZYI
Identifiers
Aliases	LRRC4, NGL-2, NAG14, leucine rich repeat containing 4
External IDs	OMIM: 610486; MGI: 2182081; HomoloGene: 36403; GeneCards: LRRC4; OMA:LRRC4 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	128,032,107 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	28,831,746 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; prefrontal cortex; ; right frontal lobe; ; bronchial epithelial cell; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; right hemisphere of cerebellum; ; cingulate gyrus; ; anterior cingulate cortex; ; cerebellar vermis;
	Top expressed in
	interventricular septum; ; dentate gyrus of hippocampal formation granule cell; ; visual cortex; ; primary visual cortex; ; piriform cortex; ; cingulate gyrus; ; superior frontal gyrus; ; lobe of cerebellum; ; hippocampus proper; ; primary motor cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein kinase inhibitor activity; protein binding;
Cellular component	cytoplasm; integral component of membrane; neuron spine; cell junction; postsynaptic membrane; dendritic spine; plasma membrane; synapse; excitatory synapse; membrane; Schaffer collateral - CA1 synapse; glutamatergic synapse; integral component of postsynaptic density membrane;
Biological process	synapse organization; postsynaptic density protein 95 clustering; regulation of synapse organization; negative regulation of protein kinase activity; cytokine-mediated signaling pathway; negative regulation of receptor signaling pathway via JAK-STAT; modulation of chemical synaptic transmission; synaptic membrane adhesion; excitatory synapse assembly;
	Sources:Amigo / QuickGO
Orthologs
	64101
	192198
	ENSG00000128594
	ENSMUSG00000049939
	Q9HBW1
	Q99PH1
	NM_022143
	NM_138682
	NP_071426
	NP_619623
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine-rich repeat-containing protein 4 is a protein that in humans is encoded by the LRRC4 gene.

This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown. Also it has been identified as a possible pathogenic gene involved in the neurogenic inflammation in rosacea.