LRRTM1

LRRTM1
Identifiers
Aliases	LRRTM1, entrez:347730, leucine rich repeat transmembrane neuronal 1
External IDs	OMIM: 610867; MGI: 2389173; HomoloGene: 41763; GeneCards: LRRTM1; OMA:LRRTM1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	80,304,752 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	77,234,774 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; prefrontal cortex; ; nucleus accumbens; ; caudate nucleus; ; middle temporal gyrus; ; putamen; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex; ; right frontal lobe;
	Top expressed in
	lateral geniculate nucleus; ; medial dorsal nucleus; ; medial geniculate nucleus; ; hippocampus proper; ; barrel cortex; ; subiculum; ; temporal lobe; ; dentate gyrus; ; piriform cortex; ; nucleus accumbens;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein kinase inhibitor activity; molecular function;
Cellular component	integral component of membrane; postsynaptic membrane; membrane; growth cone; plasma membrane; synapse; excitatory synapse; cell surface; axon; cell junction; endoplasmic reticulum; extracellular space; extracellular matrix; glutamatergic synapse; GABA-ergic synapse; integral component of postsynaptic membrane; integral component of postsynaptic specialization membrane;
Biological process	locomotory behavior; negative regulation of protein kinase activity; cytokine-mediated signaling pathway; negative regulation of receptor internalization; synapse organization; exploration behavior; protein localization to synapse; long-term potentiation; negative regulation of receptor signaling pathway via JAK-STAT; positive regulation of synapse assembly; biological process; regulation of postsynaptic density assembly; regulation of presynapse assembly;
	Sources:Amigo / QuickGO
Orthologs
	347730
	74342
	ENSG00000162951
	ENSMUSG00000060780
	Q86UE6
	Q8K377
	NM_178839
	NM_028880; NM_001362109
	NP_849161
	NP_083156; NP_001349038
	Wikidata
View/Edit Human	View/Edit Mouse

LRRTM1 is a brain-expressed imprinted gene that encodes a leucine-rich repeat transmembrane protein that interacts with neurexins and neuroligins to modulate synaptic cell adhesion in neurons. As the name implies, its protein product is a transmembrane protein that contains many leucine rich repeats. It is expressed during the development of specific forebrain structures and shows a variable pattern of maternal downregulation (genomic imprinting).