LSM4

LSM4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3JCR
Identifiers
Aliases	LSM4, GRP, YER112W, LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
External IDs	OMIM: 607284; MGI: 1354692; HomoloGene: 134555; GeneCards: LSM4; OMA:LSM4 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	18,323,112 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	71,131,402 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; right testis; ; left testis; ; ventricular zone; ; right adrenal gland; ; right adrenal cortex; ; left adrenal cortex; ; embryo; ; ganglionic eminence; ; apex of heart;
	Top expressed in
	yolk sac; ; thymus; ; bone marrow; ; lens; ; epiblast; ; ventricular zone; ; proximal tubule; ; embryo; ; ileum; ; ganglionic eminence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; U6 snRNA binding; RNA binding; PH domain binding;
Cellular component	spliceosomal tri-snRNP complex; U6 snRNP; P-body; nucleoplasm; neuron projection; spliceosomal complex; nucleus; cytosol; membrane; protein-containing complex; U4/U6 x U5 tri-snRNP complex; U2-type precatalytic spliceosome; Lsm2-8 complex;
Biological process	RNA processing; mRNA processing; spliceosomal snRNP assembly; spliceosomal complex assembly; P-body assembly; exonucleolytic catabolism of deadenylated mRNA; RNA splicing; mRNA splicing, via spliceosome; nuclear-transcribed mRNA catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	25804
	50783
	ENSG00000130520
	ENSMUSG00000031848
	Q9Y4Z0
	Q9QXA5
	NM_012321; NM_001252129
	NM_015816; NM_001359042
	NP_001239058; NP_036453
	NP_056631; NP_001345971
	Wikidata
View/Edit Human	View/Edit Mouse

U6 snRNA-associated Sm-like protein LSm4 is a protein that in humans is encoded by the LSM4 gene.

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM]