Lanosterol synthase

LSS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1W6J, 1W6K
Identifiers
Aliases	LSS, OSC, CTRCT44, lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase), lanosterol synthase, HYPT14, APMR4
External IDs	OMIM: 600909; MGI: 1336155; HomoloGene: 37408; GeneCards: LSS; OMA:LSS - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	46,228,824 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	76,392,972 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; C1 segment; ; skin of leg; ; right ovary; ; skin of abdomen; ; corpus callosum; ; pituitary gland; ; right hemisphere of cerebellum; ; ventricular zone; ; left ovary;
	Top expressed in
	lip; ; epithelium of small intestine; ; skin of external ear; ; Ileal epithelium; ; Paneth cell; ; hair follicle; ; gastrula; ; transitional epithelium of urinary bladder; ; sciatic nerve; ; ciliary body;
	More reference expression data
	n/a
Gene ontology
Molecular function	isomerase activity; intramolecular transferase activity; lanosterol synthase activity; beta-amyrin synthase activity;
Cellular component	lipid droplet; endoplasmic reticulum membrane; endoplasmic reticulum; membrane;
Biological process	regulation of protein stability; lipid metabolism; steroid biosynthetic process; cholesterol biosynthetic process; regulation of cholesterol biosynthetic process; triterpenoid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	4047
	16987
	ENSG00000160285; ENSG00000281289
	ENSMUSG00000033105
	P48449
	Q8BLN5
	NM_001001438; NM_001145436; NM_001145437; NM_002340
	NM_146006
	NP_001001438; NP_001138908; NP_001138909; NP_002331
	NP_666118
	Wikidata
View/Edit Human	View/Edit Mouse

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lanosterol synthase
lanosterol synthase
Identifiers
EC no.	5.4.99.7
CAS no.	9032-71-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
Search
PMC	articles
PubMed	articles
NCBI	proteins

Lanosterol synthase (EC 5.4.99.7) is an oxidosqualene cyclase (OSC) enzyme that converts (S)-2,3-oxidosqualene to a protosterol cation and finally to lanosterol. Lanosterol is a key four-ringed intermediate in cholesterol biosynthesis. In humans, lanosterol synthase is encoded by the LSS gene.

In eukaryotes, lanosterol synthase is an integral monotopic protein associated with the cytosolic side of the endoplasmic reticulum. Some evidence suggests that the enzyme is a soluble, non-membrane bound protein in the few prokaryotes that produce it.

Due to the enzyme's role in cholesterol biosynthesis, there is interest in lanosterol synthase inhibitors as potential cholesterol-reducing drugs, to complement existing statins.