LU domain

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1cds :28-95 1cdr :28-95 1cdq :28-95 1erg :28-95 1ywhC:25-99 1vyeA:23-80

u-PAR/Ly-6 domain
u-PAR/Ly-6 domain
	Crystallographic structure of non-glycosylated human CD59.
Identifiers
Symbol	UPAR_LY6
Pfam	PF00021
InterPro	IPR001526
PROSITE	PDOC00756
CATH	1erg
SCOP2	1erg / SCOPe / SUPFAM
CDD	cd00117
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1cds :28-95 1cdr :28-95 1cdq :28-95 1erg :28-95 1ywhC:25-99 1vyeA:23-80

The LU domain (Ly-6 antigen/uPAR) is an evolutionarily conserved protein domain of the three-finger protein superfamily. This domain is found in the extracellular domains of cell-surface receptors and in either GPI-anchored or secreted globular proteins, for example the Ly-6 family, CD59, and Sgp-2.

A variety of GPI-linked cell-surface glycoproteins are composed of one or more copies of a conserved LU domain of about 100 amino-acid residues. Among these proteins, most contain only a single LU domain, though small numbers of exceptions are known; well-studied family member uPAR has three tandem LU domains.