LY-178210

LY-178210
Clinical data
Other names	LY178210; LY-228729; LY228729
Drug class	Serotonin 5-HT1A receptor partial agonist
Identifiers
	IUPAC name 4-(dipropylamino)-1,3,4,5-tetrahydrobenzo[cd]indole-6-carboxamide;
CAS Number	114943-19-0;
PubChem CID	60845;
ChemSpider	54832;
ChEMBL	ChEMBL296753;
CompTox Dashboard (EPA)	DTXSID20905583 ;
Chemical and physical data
Formula	C18H25N3O
Molar mass	299.418 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCN(CCC)C1CC2=CNC3=C2C(=C(C=C3)C(=O)N)C1;
	InChI InChI=1S/C18H25N3O/c1-3-7-21(8-4-2)13-9-12-11-20-16-6-5-14(18(19)22)15(10-13)17(12)16/h5-6,11,13,20H,3-4,7-10H2,1-2H3,(H2,19,22); Key:YTOJFUORFUYGSV-UHFFFAOYSA-N;

LY-178210 is a selective and highly potent serotonin 5-HT_1A receptor partial agonist. It has an affinity (K_i) of 0.67 nM for the serotonin 5-HT_1A receptor. The drug has high selectivity for this receptor over 12 other assessed targets, including the serotonin 5-HT_1D, 5-HT_2A, 5-HT_2C, and 5-HT₃ receptors among others (K_i = ≥380–4,000 nM). LY-178210 is a tricyclic simplified or partial ergoline and is structurally related to LSD. It was described as a potential clinical development candidate but was not further developed and was never marketed. The drug was first reported in the scientific literature by 1990.