LY6E

LY6E
Identifiers
Aliases	LY6E, RIG-E, RIGE, SCA-2, SCA2, TSA-1, lymphocyte antigen 6 complex, locus E, lymphocyte antigen 6 family member E
External IDs	OMIM: 601384; MGI: 106651; HomoloGene: 56411; GeneCards: LY6E; OMA:LY6E - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	143,023,832 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	74,831,754 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; granulocyte; ; olfactory zone of nasal mucosa; ; stromal cell of endometrium; ; placenta; ; right ovary; ; right lung; ; upper lobe of left lung; ; right frontal lobe; ; hippocampus proper;
	Top expressed in
	lactiferous gland; ; superior surface of tongue; ; gallbladder; ; corneal stroma; ; cardiac muscles; ; cardiac muscle tissue of left ventricle; ; CA3 field; ; right kidney; ; perirhinal cortex; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	acetylcholine receptor inhibitor activity;
Cellular component	integral component of plasma membrane; membrane; anchored component of membrane; extracellular region; plasma membrane;
Biological process	cell surface receptor signaling pathway; negative regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	4061
	17069
	ENSG00000278032; ENSG00000160932
	ENSMUSG00000022587
	Q16553
	Q64253
	NM_002346; NM_001127213
NM_001164036; NM_001164037; NM_001164038; NM_001164039; NM_001164040;
	NM_008529; NM_001374138
	NP_001120685; NP_002337
NP_001157508; NP_001157509; NP_001157510; NP_001157511; NP_001157512;
	NP_032555; NP_001361067
	Wikidata
View/Edit Human	View/Edit Mouse

Lymphocyte antigen 6E is a protein that in humans is encoded by the LY6E gene. Increased expression of Ly6E is associated with poor survival outcome in multiple malignancies as determined by a survey of more than 130 published clinical studies of gene expression studies on cancer tissue samples and adjacent normal tissues. Ly6E is associated with drug resistance and tumor immune escape in breast cancer. Further research is required to validate Ly6E for translation research.