Lymphocyte antigen 96

LY96
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E56, 2E59, 2Z65, 3FXI, 3ULA, 4G8A
Identifiers
Aliases	LY96, ESOP-1, MD-2, MD2, ly-96, lymphocyte antigen 96
External IDs	OMIM: 605243; MGI: 1341909; HomoloGene: 9109; GeneCards: LY96; OMA:LY96 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	74,029,079 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	16,779,835 bp
RNA expression pattern
	Top expressed in
	monocyte; ; periodontal fiber; ; granulocyte; ; spleen; ; testicle; ; appendix; ; lymph node; ; gallbladder; ; decidua; ; trabecular bone;
	Top expressed in
	blastocyst; ; granulocyte; ; morula; ; right kidney; ; zygote; ; seminal vesicula; ; parotid gland; ; epithelium of small intestine; ; proximal tubule; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	coreceptor activity; protein binding; lipopolysaccharide immune receptor activity; lipopolysaccharide binding; Toll-like receptor 4 binding;
Cellular component	intrinsic component of plasma membrane; plasma membrane; extracellular region; lipopolysaccharide receptor complex; endosome membrane; extracellular space;
Biological process	toll-like receptor 4 signaling pathway; immune system process; MyD88-dependent toll-like receptor signaling pathway; positive regulation of lipopolysaccharide-mediated signaling pathway; TRIF-dependent toll-like receptor signaling pathway; cellular defense response; cell surface receptor signaling pathway; response to lipopolysaccharide; positive regulation of tumor necrosis factor production; inflammatory response; cellular response to lipopolysaccharide; detection of lipopolysaccharide; I-kappaB kinase/NF-kappaB signaling; MyD88-independent toll-like receptor signaling pathway; lipopolysaccharide-mediated signaling pathway; negative regulation of MyD88-independent toll-like receptor signaling pathway; innate immune response; necroptosis; apoptotic signaling pathway; toll-like receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	23643
	17087
	ENSG00000154589
	ENSMUSG00000025779
	Q9Y6Y9
	Q9JHF9
	NM_001195797; NM_015364
	NM_001159711; NM_016923
	NP_001182726; NP_056179
	NP_001153183; NP_058619
	Wikidata
View/Edit Human	View/Edit Mouse

Lymphocyte antigen 96, also known as "Myeloid Differentiation factor 2 (MD-2)," is a protein that in humans is encoded by the LY96 gene.

The protein encoded by this gene is involved in binding lipopolysaccharide with Toll-Like Receptor (TLR4).