LYPD1

LYPD1
Identifiers
Aliases	LYPD1, LYPDC1, PHTS, LY6/PLAUR domain containing 1
External IDs	OMIM: 610450; MGI: 1919835; HomoloGene: 16937; GeneCards: LYPD1; OMA:LYPD1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	132,671,579 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	125,840,838 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; nucleus accumbens; ; caudate nucleus; ; putamen; ; ventricular zone; ; Hypothalamus; ; Amygdala; ; pituitary gland; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	glossopharyngeal ganglion; ; ganglion of vagus nerve; ; dentate gyrus of hippocampal formation granule cell; ; cuneiform bones; ; cranial nervi; ; inferior ganglion of vagus nerve; ; Amygdala; ; olfactory nerve; ; primary visual cortex; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	acetylcholine receptor binding; acetylcholine receptor inhibitor activity;
Cellular component	membrane; anchored component of membrane; extracellular region; plasma membrane;
Biological process	response to nicotine; behavioral fear response; negative regulation of signaling receptor activity; synaptic transmission, cholinergic; cell activation; acetylcholine receptor signaling pathway; negative regulation of protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	116372
	72585
	ENSG00000150551
	ENSMUSG00000026344
	Q8N2G4
	Q8BLC3
	NM_001077427; NM_144586; NM_001321234; NM_001321235
	NM_145100; NM_001311089; NM_001311090
	NP_001070895; NP_001308163; NP_001308164; NP_653187
	NP_001298018; NP_001298019; NP_659568
	Wikidata
View/Edit Human	View/Edit Mouse

Ly6/PLAUR domain-containing protein 1 is a protein that in humans is encoded by the LYPD1 gene.

This protein is also known as Lynx2, a member of the Lynx family of neurotransmitter receptor-binding proteins. Transgenic mice without Lynx2 expression have increased anxiety-related behaviors.