Lanthanide-dependent methanol dehydrogenase
| Lanthanide-dependent methanol dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
The enzyme as folded by AlphaFold | |||||||||
| Identifiers | |||||||||
| EC no. | 1.1.2.10 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Lanthanide-dependent methanol dehydrogenase is an oxidoreductase enzyme involved in methane metabolic pathways in microbial metabolism. This enzyme was first isolated from the methylacidiphilum fumariolicum and others in the methylacidiphilum species. The enzyme requires La3+, Ce3+, Pr3+ or Nd3+. Higher lanthanides show decreasing activity with Sm3+, Eu3+ and Gd3+. The lanthanide atom in the enzyme is coordinated by pyrroloquinoline quinone. The enzyme catalyzes the following reaction
- 2 Fe(III)-cytochrome cL + methanol -> 2 Fe(II)-cytochrome cL + formaldehyde + 2 H+