Leprecan

Search for
Structures	Swiss-model
Domains	InterPro

leucine proline-enriched proteoglycan (leprecan) 1
leucine proline-enriched proteoglycan (leprecan) 1
Identifiers
Symbol	P3H1, LEPRE1
NCBI gene	64175
HGNC	19316
OMIM	610339
PDB	8K0M
RefSeq	NM_022356
UniProt	Q32P28
Other data
Locus	Chr. 1 p34.1
Structures
Search for
Structures	Swiss-model
Domains	InterPro

P3H1
Identifiers
Aliases	P3H1, GROS1, OI8, LEPRE1, prolyl 3-hydroxylase 1
External IDs	OMIM: 610339; MGI: 1888921; HomoloGene: 10509; GeneCards: P3H1; OMA:P3H1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	42,767,084 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	119,106,172 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; anterior pituitary; ; tibial nerve; ; tibia; ; cartilage tissue; ; right ovary; ; left ovary; ; canal of the cervix; ; ascending aorta; ; body of uterus;
	Top expressed in
	calvaria; ; cumulus cell; ; tail of embryo; ; dermis; ; genital tubercle; ; molar; ; fossa; ; facial skeleton; ; umbilical cord; ; long bone;
	More reference expression data
	n/a
Gene ontology
Molecular function	iron ion binding; L-ascorbic acid binding; collagen binding; protein-containing complex binding; dioxygenase activity; metal ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity; procollagen-proline 3-dioxygenase activity; molecular function; protein binding;
Cellular component	protein-containing complex; endoplasmic reticulum lumen; membrane; extracellular region; endoplasmic reticulum; extracellular exosome; collagen-containing extracellular matrix;
Biological process	regulation of protein secretion; protein stabilization; protein folding; negative regulation of post-translational protein modification; bone development; negative regulation of cell population proliferation; protein hydroxylation; chaperone-mediated protein folding; peptidyl-proline hydroxylation; collagen metabolic process; positive regulation of neuron projection development;
	Sources:Amigo / QuickGO
Orthologs
	64175
	56401
	ENSG00000117385
	ENSMUSG00000028641
	Q32P28
	Q3V1T4
	NM_001146289; NM_001243246; NM_022356
	NM_001042411; NM_001286148; NM_019782; NM_019783
	NP_001139761; NP_001230175; NP_071751
	NP_001035874; NP_001273077; NP_062756; NP_062757
	Wikidata
View/Edit Human	View/Edit Mouse

Leprecan (P3H1) is a protein associated with osteogenesis imperfecta type VIII.

Leprecan is part of a superfamily of 2OG-Fe(II) dioxygenase, along with DNA repair protein AlkB, and disease resistant EGL-9. The enzyme was found to be a type of hydroxylases used in the substrate formation of protein glycosylation.