Leptin receptor

LEPR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3V6O
Identifiers
Aliases	LEPR, CD295, LEP-R, LEPRD, OB-R, OBR, leptin receptor
External IDs	OMIM: 601007; MGI: 104993; HomoloGene: 1731; GeneCards: LEPR; OMA:LEPR - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	65,641,559 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	101,672,549 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; Epithelium of choroid plexus; ; trigeminal ganglion; ; pericardium; ; skin of hip; ; oral cavity; ; mucosa of pharynx; ; lower lobe of lung; ; skin of thigh; ; urethra;
	Top expressed in
	lumbar spinal ganglion; ; Epithelium of choroid plexus; ; dermis; ; right lung; ; mesenteric lymph nodes; ; aortic valve; ; membranous bone; ; Dermatocranium; ; right lung lobe; ; Paneth cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	leptin receptor activity; protein binding; identical protein binding; cytokine receptor activity; transmembrane signaling receptor activity; peptide hormone binding; cytokine binding;
Cellular component	integral component of membrane; membrane; receptor complex; plasma membrane; extracellular region; basolateral plasma membrane; external side of plasma membrane;
Biological process	sexual reproduction; glucose homeostasis; leptin-mediated signaling pathway; cholesterol metabolic process; negative regulation of hydrolase activity; regulation of feeding behavior; multicellular organism development; negative regulation of gluconeogenesis; cell surface receptor signaling pathway; T cell differentiation; angiogenesis; energy homeostasis; bone growth; energy reserve metabolic process; response to leptin; negative regulation of autophagy; regulation of bone remodeling; phagocytosis; positive regulation of cold-induced thermogenesis; glycogen metabolic process; glial cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	3953
	16847
	ENSG00000116678
	ENSMUSG00000057722
	P48357
	P48356
NM_002303; NM_001003679; NM_001003680; NM_001198687; NM_001198688;
	NM_001198689
	NM_001122899; NM_010704; NM_146146
NP_001003679; NP_001003680; NP_001185616; NP_001185617; NP_001185618;
	NP_002294
	NP_001116371; NP_034834; NP_666258
	Wikidata
View/Edit Human	View/Edit Mouse

Leptin receptor, also known as LEP-R or OB-R, is a type I cytokine receptor, a protein that in humans is encoded by the LEPR gene. LEP-R functions as a receptor for the fat cell-specific hormone leptin. LEP-R has also been designated as CD295 (cluster of differentiation 295). Its location is the cell membrane, and it has extracellular, trans-membrane and intracellular sections (protein regions).