Leukotriene-A4 hydrolase
| leukotriene-A4 hydrolase | |||||||||
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| Identifiers | |||||||||
| EC no. | 3.3.2.6 | ||||||||
| CAS no. | 90119-07-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| leukotriene A4 hydrolase | |||||||
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Crystallographic structure of LTA4H (rainbow colored N-terminus = blue, C-terminus = red) complexed with the protease inhibitor bestatin (space-filling model, carbon = white, oxygen = red, nitrogen = blue) based on the PDB: 1HS6 structure. | |||||||
| Identifiers | |||||||
| Symbol | LTA4H | ||||||
| NCBI gene | 4048 | ||||||
| HGNC | 6710 | ||||||
| OMIM | 151570 | ||||||
| PDB | 1SQM | ||||||
| RefSeq | NM_000895 | ||||||
| UniProt | P09960 | ||||||
| Other data | |||||||
| EC number | 3.3.2.6 | ||||||
| Locus | Chr. 12 q22 | ||||||
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Leukotriene-A4 hydrolase is an enzyme that catalyzes the reaction which converts Leukotriene A4 to Leukotriene B4. It is a bifunctional zinc enzyme (EC 3.3.2.6) with different amino acids attached to it to aid in the catalysis of the reaction. It also acts as an aminopeptidase. Leukotriene-A4 hydrolase is a cytosolic protein and is found in almost all mammalian cells, tissues and organelles that have been examined.