Li–Fraumeni syndrome

Li–Fraumeni syndrome
Other namesSarcoma family syndrome of Li and Fraumeni, SBLA
Li–Fraumeni syndrome is inherited via an autosomal dominant manner
SpecialtyOncology, medical genetics, neurology 

Li–Fraumeni syndrome (LFS) is a rare, autosomal dominant, hereditary disorder that predisposes carriers to cancer development. It was named after two American physicians, Frederick Pei Li and Joseph F. Fraumeni Jr., who first recognized the syndrome after reviewing the medical records and death certificates of childhood rhabdomyosarcoma patients. The disease is also known as SBLA, for the Sarcoma, Breast, Leukemia, and Adrenal Gland cancers that it is known to cause.

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