Linzagolix

Linzagolix
Clinical data
Pronunciation	/ˌlɪnzəˈɡoʊlɪks/; LINZ-ə-GOH-liks
Trade names	Yselty
Other names	KLH-2109; OBE-2109
Routes of; administration	By mouth
Drug class	GnRH modulator; GnRH antagonist; Antigonadotropin
ATC code	H01CC04 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); EU: Rx-only;
Identifiers
	IUPAC name 3-{5-[(2,3-difluoro-6-methoxyphenyl)methoxy]-2-fluoro-4-methoxyphenyl}-2,4-dioxo-1,2,3,4-tetrahydrothieno[3,4-d]pyrimidine-5-carboxylic acid;
CAS Number	935283-04-8; as choline: 1321816-57-2;
PubChem CID	16656889;
ChemSpider	17590169;
UNII	7CDW97HUEX;
KEGG	D11608; as choline: D11609;
ChEMBL	ChEMBL3668014; as choline: ChEMBL4298171;
Chemical and physical data
Formula	C22H15F3N2O7S
Molar mass	508.42 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COc1cc(F)c(-n2c(=O)[nH]c3csc(C(=O)O)c3c2=O)cc1OCc1c(OC)ccc(F)c1F;
	InChI InChI=1S/C22H15F3N2O7S/c1-32-14-4-3-10(23)18(25)9(14)7-34-16-6-13(11(24)5-15(16)33-2)27-20(28)17-12(26-22(27)31)8-35-19(17)21(29)30/h3-6,8H,7H2,1-2H3,(H,26,31)(H,29,30); Key:BMAAMIIYNNPHAB-UHFFFAOYSA-N;

Linzagolix, sold under the brand name Yselty, is a medication used in the treatment of uterine fibroids and endometriosis. Linzagolix is a small-molecule, non-peptide, orally active gonadotropin-releasing hormone antagonist (GnRH antagonist) developed by Kissei Pharmaceutical and ObsEva.

In June 2022, it was approved for medical use in the European Union and in the United Kingdom.

Clinical data


Pronunciation	/ˌlɪnzəˈɡoʊlɪks/ LINZ-ə-GOH-liks
Trade names	Yselty
Other names	KLH-2109; OBE-2109
Routes of administration	By mouth
Drug class	GnRH modulator; GnRH antagonist; Antigonadotropin
ATC code	H01CC04 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) UK: POM (Prescription only) EU: Rx-only
Identifiers
IUPAC name 3-{5-[(2,3-difluoro-6-methoxyphenyl)methoxy]-2-fluoro-4-methoxyphenyl}-2,4-dioxo-1,2,3,4-tetrahydrothieno[3,4-d]pyrimidine-5-carboxylic acid
CAS Number	935283-04-8 as choline: 1321816-57-2
PubChem CID	16656889
ChemSpider	17590169
UNII	7CDW97HUEX
KEGG	D11608 as choline: D11609
ChEMBL	ChEMBL3668014 as choline: ChEMBL4298171
Chemical and physical data
Formula	C₂₂H₁₅F₃N₂O₇S
Molar mass	508.42 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES COc1cc(F)c(-n2c(=O)[nH]c3csc(C(=O)O)c3c2=O)cc1OCc1c(OC)ccc(F)c1F
InChI InChI=1S/C22H15F3N2O7S/c1-32-14-4-3-10(23)18(25)9(14)7-34-16-6-13(11(24)5-15(16)33-2)27-20(28)17-12(26-22(27)31)8-35-19(17)21(29)30/h3-6,8H,7H2,1-2H3,(H,26,31)(H,29,30) Key:BMAAMIIYNNPHAB-UHFFFAOYSA-N