Dihydrolipoamide dehydrogenase

DLD
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3RNM, 1ZMC, 1ZMD, 1ZY8, 2F5Z
Identifiers
Aliases	DLD, DLDD, DLDH, E3, GCSL, LAD, PHE3, dihydrolipoamide dehydrogenase, Dihydrolipoamide dehydrogenase, OGDC-E3
External IDs	OMIM: 238331; MGI: 107450; HomoloGene: 84; GeneCards: DLD; OMA:DLD - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	107,931,730 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	31,401,452 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; thoracic diaphragm; ; Skeletal muscle tissue of rectus abdominis; ; vastus lateralis muscle; ; body of tongue; ; mucosa of sigmoid colon; ; jejunal mucosa; ; rectum;
	Top expressed in
	saccule; ; cardiac muscle tissue of left ventricle; ; otic placode; ; tail of embryo; ; extraocular muscle; ; intercostal muscle; ; soleus muscle; ; extensor digitorum longus muscle; ; interventricular septum; ; plantaris muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	flavin adenine dinucleotide binding; NAD binding; dihydrolipoyl dehydrogenase activity; oxidoreductase activity; pyruvate dehydrogenase (NAD+) activity; lipoamide binding; oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor; electron transfer activity; protein binding;
Cellular component	oxoglutarate dehydrogenase complex; myelin sheath; pyruvate dehydrogenase complex; cilium; acrosomal matrix; nucleoplasm; mitochondrial matrix; mitochondrion; acrosomal vesicle; cytoplasmic vesicle; motile cilium; cell projection; nucleus;
Biological process	mitochondrial acetyl-CoA biosynthetic process from pyruvate; regulation of membrane potential; ageing; branched-chain amino acid catabolic process; tricarboxylic acid cycle; 2-oxoglutarate metabolic process; lysine catabolic process; regulation of acetyl-CoA biosynthetic process from pyruvate; cell redox homeostasis; proteolysis; lipoate metabolic process; dihydrolipoamide metabolic process; gastrulation; pyruvate metabolic process; sperm capacitation; acetyl-CoA biosynthetic process from pyruvate; mitochondrial electron transport, NADH to ubiquinone; cellular nitrogen compound metabolic process; histone succinylation;
	Sources:Amigo / QuickGO
Orthologs
	1738
	13382
	ENSG00000091140
	ENSMUSG00000020664
	P09622
	O08749
	NM_001289752; NM_000108; NM_001289750; NM_001289751
	NM_007861
	NP_000099; NP_001276679; NP_001276680; NP_001276681
	NP_031887
	Wikidata
View/Edit Human	View/Edit Mouse

Dihydrolipoamide dehydrogenase (DLD), also known as dihydrolipoyl dehydrogenase, mitochondrial, is an enzyme that in humans is encoded by the DLD gene. DLD is a flavoprotein enzyme that oxidizes dihydrolipoamide to lipoamide.

Dihydrolipoamide dehydrogenase (DLD) is a mitochondrial enzyme that plays a vital role in energy metabolism in eukaryotes. This enzyme is required for the complete reaction of at least five different multi-enzyme complexes. Additionally, DLD is a flavoenzyme oxidoreductase that contains a reactive disulfide bridge and a FAD cofactor that are directly involved in catalysis. The enzyme associates into tightly bound homodimers required for its enzymatic activity.