Lipoprotein(a)

LPA
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1I71, 1JFN, 1KIV, 2FEB, 4BV5, 4BV7, 4BVC, 4BVD, 4BVV, 4BVW, 3KIV, 4KIV
Identifiers
Aliases	LPA, AK38, APOA, LP, Lipoprotein(a), Lp(a)
External IDs	HomoloGene: 87856; GeneCards: LPA; OMA:LPA - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	160,664,275 bp
RNA expression pattern
	Top expressed in
	liver; ; right lobe of liver; ; testicle; ; gonad; ; palpebral conjunctiva; ; prefrontal cortex; ; olfactory zone of nasal mucosa; ; body of pancreas; ; human kidney; ; urinary bladder;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	fibronectin binding; apolipoprotein binding; peptidase activity; endopeptidase inhibitor activity; heparin binding; serine-type endopeptidase activity; serine-type peptidase activity; protein binding; hydrolase activity;
Cellular component	extracellular region; plasma lipoprotein particle;
Biological process	lipid transport; blood circulation; proteolysis; lipid metabolism; negative regulation of endopeptidase activity; low-density lipoprotein particle remodeling;
	Sources:Amigo / QuickGO
Orthologs
	4018
	n/a
	ENSG00000198670
	n/a
	P08519
	n/a
	NM_005577
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Lipoprotein(a) is a low-density lipoprotein variant containing a protein called apolipoprotein(a). Genetic and epidemiological studies have identified lipoprotein(a) as a risk factor for atherosclerosis and related diseases, such as coronary heart disease and stroke.

Lipoprotein(a) was discovered in 1963 by Kåre Berg. The human gene encoding apolipoprotein(a) was successfully cloned in 1987.