List of primary immunodeficiencies

This is a list of primary immunodeficiencies (PID), which are immune deficiencies that are not secondary to another condition.

The International Union of Immunological Societies recognizes nine classes of primary immunodeficiencies, totaling approximately 430 conditions. A 2014 update of the classification guide added a 9th category and added 30 new gene defects from the prior 2009 version. The most recent classification was released in 2019. The number of identified conditions continues to grow over time as more research is done.

The impact of primary immunodeficiencies ranges from mild to severe based on the condition.

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