Loop diuretic
| Loop diuretic | |
|---|---|
| Drug class | |
Structure of the loop diuretics Furosemide, Azosemide, Bumetanide, Piretanide, Torasemide, Ethacrynic acid and Etozolin | |
| Class identifiers | |
| Synonyms | High-ceiling diuretic |
| Use | congestive heart failure, nephrotic syndrome, cirrhosis, hypertension, edema |
| ATC code | C03C |
| Biological target | Na-K-Cl cotransporter |
| External links | |
| MeSH | D049994 |
| Legal status | |
| In Wikidata | |
Loop diuretics are pharmacological agents that primarily inhibit the Na-K-Cl cotransporter located on the luminal membrane of cells along the thick ascending limb of the loop of Henle. They are often used for the treatment of hypertension and edema secondary to congestive heart failure, liver cirrhosis, or chronic kidney disease. While thiazide diuretics are more effective in patients with normal kidney function, loop diuretics are more effective in patients with impaired kidney function.