Lysosomal cystine transporter family

The lysosomal cystine transporter (LCT) family (TC# 2.A.43) is part of the TOG Superfamily and includes secondary transport proteins that are derived from animals, plants, fungi and other eukaryotes. They exhibit 7 putative transmembrane α-helical spanners (TMSs) and vary in size between about 200 and 500 amino acyl residues, although most have between 300 and 400 residues.

These proteins are found in intracellular organelles of eukaryotes, many in lysosomes. The few that have been characterized transport Cystine (TC# 2.A.43.1.1), basic amino acids such as L-lysine and L-arginine (TC# 2.A.43.2.1) and drugs such as fluconazole and caspofungin (TC# 2.A.43.2.7).