Lysosome-associated membrane glycoprotein
| Lysosome-associated membrane glycoprotein (Lamp) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Lamp, LAMP (root symbol of family) | ||||||||
| Pfam | PF01299 | ||||||||
| InterPro | IPR002000 | ||||||||
| PROSITE | PDOC00280 | ||||||||
| TCDB | 9.A.16 | ||||||||
| OPM superfamily | 423 | ||||||||
| OPM protein | 2mom | ||||||||
| Membranome | 51 | ||||||||
| |||||||||
Lysosome-associated membrane glycoproteins (LAMPs) are integral membrane proteins, specific to lysosomes, and whose exact biological function is not yet clear. Structurally, the lamp proteins consist of two internally homologous lysosome-luminal domains separated by a proline-rich hinge region; at the C-terminal extremity there is a transmembrane region (TM) followed by a very short cytoplasmic tail (C). In each of the duplicated domains, there are two conserved disulfide bonds. This structure is schematically represented in the figure below.
+-----+ +-----+ +-----+ +-----+
| | | | | | | |
xCxxxxxCxxxxxxxxxxxxCxxxxxCxxxxxxxxxCxxxxxCxxxxxxxxxxxxCxxxxxCxxxxxxxx
+--------------------------++Hinge++--------------------------++TM++C+
In mammals, there are two closely related types of LAMP: LAMP1 and LAMP2.
CD68 (also called gp110 or macrosialin) is a heavily glycosylated integral membrane protein whose structure consists of a mucin-like domain followed by a proline-rich hinge; a single LAMP-like domain; a transmembrane region and a short cytoplasmic tail.
CD molecules are leucocyte antigens on cell surfaces. CD antigen nomenclature is updated at Protein Reviews On The Web (https://web.archive.org/web/20080920090434/http://mpr.nci.nih.gov/prow/).