MACF1

MACF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4Z6G
Identifiers
Aliases	MACF1, ABP620, ACF7, MACF, OFC4, microtubule-actin crosslinking factor 1, LIS9, microtubule actin crosslinking factor 1, Lnc-PMIF
External IDs	OMIM: 608271; MGI: 108559; HomoloGene: 136220; GeneCards: MACF1; OMA:MACF1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	39,487,177 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	123,684,360 bp
RNA expression pattern
	Top expressed in
	inferior olivary nucleus; ; dorsal motor nucleus of vagus nerve; ; right lung; ; Achilles tendon; ; epithelium of colon; ; corpus callosum; ; middle temporal gyrus; ; saphenous vein; ; upper lobe of left lung; ; ventricular zone;
	Top expressed in
	left lung lobe; ; paraventricular nucleus of hypothalamus; ; mammillary body; ; right lung; ; superior colliculus; ; ventromedial nucleus; ; arcuate nucleus; ; right lung lobe; ; cerebellar vermis; ; ventral tegmental area;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; calcium ion binding; actin binding; microtubule binding; protein binding; RNA binding; cadherin binding; ATPase activity; microtubule minus-end binding; actin filament binding; structural molecule activity; cytoskeletal protein binding;
Cellular component	Golgi apparatus; cell projection; membrane; microtubule; ruffle membrane; plasma membrane; cytoskeleton; cytoplasm; intermediate filament; actin cytoskeleton;
Biological process	Wnt signaling pathway; Golgi to plasma membrane protein transport; wound healing; positive regulation of axon extension; regulation of microtubule-based process; regulation of epithelial cell migration; positive regulation of Wnt signaling pathway; regulation of cell migration; regulation of focal adhesion assembly; cytoskeleton organization; intermediate filament cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	23499
	11426
	ENSG00000127603
	ENSMUSG00000028649
	Q9UPN3
	Q9QXZ0
	NM_012090; NM_033044; NM_001394062
	NM_001199136; NM_001199137; NM_009600
	NP_036222
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 is a protein that in humans is encoded by the MACF1 gene.

MACF1 encodes a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. MACF1 is a member of a family of proteins that form bridges between different cytoskeletal elements. This protein facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions.

MACF1 belongs to a subset of +TIPs or proteins which bind to growing microtubule ends called spectraplakins. Spectraplakins characteristically have distinctive microtubule and actin binding domains, which allow MACF1 to bind to both cytoskeletal elements. MACF1 goes by many names and is also called ACF7 or actin cross-linking factor 7, MACF, macrophin, trabeculin α, and ABP620. Alternatively spliced transcript variants encoding distinct isoforms of MACF1 have been described. MACF1 is also an important protein for cell migration in processes such as wound healing.