MAD2L1

MAD2L1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DUJ, 1GO4, 1KLQ, 1S2H, 2QYF, 2V64, 2VFX, 3GMH
Identifiers
Aliases	MAD2L1, HSMAD2, MAD2, MAD2 mitotic arrest deficient-like 1 (yeast), mitotic arrest deficient 2 like 1
External IDs	OMIM: 601467; MGI: 1860374; HomoloGene: 1768; GeneCards: MAD2L1; OMA:MAD2L1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	120,066,858 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	66,524,204 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; ventricular zone; ; embryo; ; ganglionic eminence; ; gonad; ; epithelium of nasopharynx; ; bone marrow; ; mucosa of transverse colon; ; amniotic fluid; ; rectum;
	Top expressed in
	zygote; ; secondary oocyte; ; primitive streak; ; tail of embryo; ; medial ganglionic eminence; ; abdominal wall; ; genital tubercle; ; primary oocyte; ; fetal liver hematopoietic progenitor cell; ; epiblast;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; protein binding; identical protein binding; protein C-terminus binding;
Cellular component	cytoplasm; cytosol; spindle pole; nuclear pore; chromosome; perinuclear region of cytoplasm; mitotic spindle; chromosome, centromeric region; cytoskeleton; nucleus; kinetochore; nucleoplasm; nuclear pore nuclear basket;
Biological process	positive regulation of mitotic cell cycle spindle assembly checkpoint; negative regulation of protein catabolic process; mitotic cell cycle checkpoint signaling; negative regulation of apoptotic process; cell division; mitotic sister chromatid segregation; cell cycle; anaphase-promoting complex-dependent catabolic process; negative regulation of mitotic cell cycle; mitotic spindle assembly checkpoint signaling; negative regulation of ubiquitin protein ligase activity; regulation of mitotic cell cycle phase transition; ubiquitin-dependent protein catabolic process; establishment of mitotic spindle orientation; establishment of centrosome localization;
	Sources:Amigo / QuickGO
Orthologs
	4085
	56150
	ENSG00000164109
	ENSMUSG00000029910
	Q13257
	Q9Z1B5
	NM_002358
	NM_019499; NM_001355624
	NP_002349
	NP_062372; NP_001342553
	Wikidata
View/Edit Human	View/Edit Mouse

Mitotic spindle assembly checkpoint protein MAD2A is a protein that in humans is encoded by the MAD2L1 gene.