MAD2L2

MAD2L2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3ABD, 3ABE, 3VU7, 4EXT, 4GK0, 4GK5
Identifiers
Aliases	MAD2L2, MAD2B, POLZ2, REV7, MAD2 mitotic arrest deficient-like 2 (yeast), mitotic arrest deficient 2 like 2, FANCV
External IDs	OMIM: 604094; MGI: 1919140; HomoloGene: 4624; GeneCards: MAD2L2; OMA:MAD2L2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	11,691,650 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	148,145,699 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; left testis; ; right testis; ; granulocyte; ; gastrocnemius muscle; ; stromal cell of endometrium; ; ventricular zone; ; muscle of thigh; ; right lobe of liver; ; body of pancreas;
	Top expressed in
	genital tubercle; ; seminiferous tubule; ; tail of embryo; ; spermatocyte; ; zygote; ; ventricular zone; ; morula; ; secondary oocyte; ; external carotid artery; ; neural tube;
	More reference expression data
	n/a
Gene ontology
Molecular function	JUN kinase binding; protein binding;
Cellular component	cytoplasm; spindle; nucleoplasm; zeta DNA polymerase complex; anaphase-promoting complex; cytoskeleton; nucleus; nucleolus; cytosol; chromosome; site of double-strand break;
Biological process	DNA damage response, signal transduction resulting in transcription; regulation of transcription, DNA-templated; negative regulation of protein catabolic process; actin filament organization; negative regulation of cell-cell adhesion mediated by cadherin; negative regulation of transcription by competitive promoter binding; negative regulation of transcription by RNA polymerase II; negative regulation of DNA-binding transcription factor activity; transcription, DNA-templated; mitotic spindle assembly checkpoint signaling; positive regulation of peptidyl-serine phosphorylation; error-prone translesion synthesis; cellular response to DNA damage stimulus; cell division; positive regulation of transcription, DNA-templated; negative regulation of transcription regulatory region DNA binding; double-strand break repair; regulation of cell growth; cell cycle; negative regulation of canonical Wnt signaling pathway; negative regulation of epithelial to mesenchymal transition; negative regulation of ubiquitin protein ligase activity; DNA repair; positive regulation of isotype switching; negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining;
	Sources:Amigo / QuickGO
Orthologs
	10459
	71890
	ENSG00000116670
	ENSMUSG00000029003
	Q9UI95
	Q9D752
	NM_001127325; NM_006341
	NM_027985; NM_001305420
	NP_001120797; NP_006332
	NP_001292349; NP_082261
	Wikidata
View/Edit Human	View/Edit Mouse

Mitotic spindle assembly checkpoint protein MAD2B is a protein that in humans is encoded by the MAD2L2 gene.