MADD (gene)

MADD
Identifiers
Aliases	MADD, DENN, IG20, RAB3GEP, MAP kinase activating death domain
External IDs	OMIM: 603584; MGI: 2444672; HomoloGene: 14249; GeneCards: MADD; OMA:MADD - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	47,330,031 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	91,183,837 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; anterior pituitary; ; Brodmann area 9; ; prefrontal cortex; ; apex of heart; ; cingulate gyrus; ; left testis; ; anterior cingulate cortex; ; right testis;
	Top expressed in
	neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; cerebellar cortex; ; primary visual cortex; ; supraoptic nucleus; ; nucleus of stria terminalis; ; Region I of hippocampus proper; ; lobe of cerebellum; ; medial dorsal nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	death receptor binding; guanyl-nucleotide exchange factor activity; protein kinase activator activity; protein binding;
Cellular component	integral component of membrane; membrane; plasma membrane; cytoplasm; cytosol;
Biological process	regulation of apoptotic process; regulation of extrinsic apoptotic signaling pathway; execution phase of apoptosis; regulation of tumor necrosis factor-mediated signaling pathway; regulation of Rab protein signal transduction; regulation of cell cycle; cell surface receptor signaling pathway; regulation of extrinsic apoptotic signaling pathway via death domain receptors; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	8567
	228355
	ENSG00000110514
	ENSMUSG00000040687
	Q8WXG6
	Q80U28
NM_001135943; NM_001135944; NM_003682; NM_130470; NM_130471;
	NM_130472; NM_130473; NM_130474; NM_130475; NM_130476
NM_001177719; NM_001177720; NM_001177721; NM_001177722; NM_001177723;
	NM_001177724; NM_001177725; NM_001177726; NM_001177727; NM_001177728; NM_001177729; NM_145527
NP_001129415; NP_001129416; NP_003673; NP_569826; NP_569827;
	NP_569828; NP_569829; NP_569830; NP_569831; NP_569832; NP_001363500; NP_001363501; NP_001363502; NP_001363503; NP_001363504; NP_001363505; NP_001363506; NP_001363507; NP_001363508; NP_001363509; NP_001363510; NP_001363511; NP_001363512; NP_001363513; NP_001363514; NP_001363515; NP_001363522; NP_001363523; NP_001363524; NP_001363525; NP_001363526; NP_001363527; NP_001363528; NP_001363529; NP_001363530; NP_001363531; NP_001363532; NP_001363533; NP_001363534; NP_001363535; NP_001363536; NP_001363537; NP_001363538; NP_001363539; NP_001363540; NP_001363541; NP_001363542; NP_001363543; NP_001363544; NP_001363545; NP_001363546; NP_001363547; NP_001363548; NP_001363549; NP_001363550; NP_001363551; NP_001363552; NP_001363553; NP_001363554; NP_001363555; NP_001363556; NP_001363557; NP_001363558; NP_001363559; NP_001363560; NP_001363561; NP_001363562; NP_001363563; NP_001363564; NP_001363565; NP_001363566; NP_001363567; NP_001363568; NP_001363569; NP_001363570; NP_001363571; NP_001363572; NP_001363573; NP_001363574; NP_001363575; NP_001363576; NP_001363577; NP_001363578; NP_001363579; NP_001363580; NP_001363581; NP_001363582; NP_001363583; NP_001363584; NP_001363585; NP_001363586; NP_001363587; NP_001363588; NP_001363589; NP_001363590; NP_001363591; NP_001363592
	NP_001171190; NP_001171191; NP_663502
	Wikidata
View/Edit Human	View/Edit Mouse

MAP kinase-activating death domain protein is an enzyme that in humans is encoded by the MADD gene. MADD is one out of four of the splice variants of the human IG20 (insulinoma-glucagonoma clone 20) gene which is located on human chromosome 11.

Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. MADD is mostly expressed in the cell membrane with some cytoplasmic expression in human cells.