MAF1

MAF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3NR5
Identifiers
Aliases	MAF1, MAF1 homolog, negative regulator of RNA polymerase III
External IDs	OMIM: 610210; MGI: 1916127; HomoloGene: 49867; GeneCards: MAF1; OMA:MAF1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	144,107,611 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	76,238,580 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; apex of heart; ; muscle layer of sigmoid colon; ; popliteal artery; ; tibial arteries; ; right coronary artery; ; gastric mucosa; ; left ventricle; ; left coronary artery;
	Top expressed in
	medial ganglionic eminence; ; Rostral migratory stream; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; muscle of thigh; ; right kidney; ; thymus; ; granulocyte; ; ventricular zone; ; blood;
	More reference expression data
	n/a
Gene ontology
Molecular function	RNA polymerase III core binding; GABA receptor binding; protein binding;
Cellular component	cytoplasm; intracellular membrane-bounded organelle; plasma membrane; inhibitory synapse; intracellular anatomical structure; axon; dendrite; nucleolus; perinuclear region of cytoplasm; nucleus; nucleoplasm; cytosol; centrosome;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of transcription by RNA polymerase III;
	Sources:Amigo / QuickGO
Orthologs
	84232
	68877
	ENSG00000179632
	ENSMUSG00000022553
	Q9H063
	Q9D0U6
	NM_032272
	NM_001164607; NM_001164608; NM_026859
	NP_115648
	NP_001158079; NP_001158080; NP_081135
	Wikidata
View/Edit Human	View/Edit Mouse

Repressor of RNA polymerase III transcription MAF1 homolog is a protein that in humans is encoded by the MAF1 gene.

This gene encodes a protein that is homologous to Maf1, a Saccharomyces cerevisiae protein which is highly conserved in eukaryotic cells. S. cerevisiae Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses Pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression.