MAGEA1

MAGEA1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1W72, 3BO8
Identifiers
Aliases	MAGEA1, CT1.1, MAGE1, MAGE family member A1
External IDs	OMIM: 300016; HomoloGene: 88717; GeneCards: MAGEA1; OMA:MAGEA1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	153,183,880 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; right testis; ; left testis; ; urinary bladder; ; human musculoskeletal system; ; kidney; ; muscular system; ; muscle; ; renal cortex;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	histone deacetylase binding; protein binding;
Cellular component	cytoplasm; plasma membrane; nucleus;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; negative regulation of Notch signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4100
	n/a
	ENSG00000198681
	n/a
	P43355
	n/a
	NM_004988
	n/a
	NP_004979
	n/a
	Wikidata
View/Edit Human

Melanoma-associated antigen 1 is a protein that in humans is encoded by the MAGEA1 gene.

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.