MAGEB2

MAGEB2
Identifiers
Aliases	MAGEB2, CT3.2, DAM6, MAGE-XP-2, MAGE family member B2
External IDs	OMIM: 300098; MGI: 2148568; HomoloGene: 134515; GeneCards: MAGEB2; OMA:MAGEB2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	30,220,089 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	85,348,699 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; right testis; ; left testis; ; pancreatic ductal cell; ; skin of hip; ; optic nerve; ; skin of thigh; ; lower lobe of lung; ; placenta;
	Top expressed in
	embryo; ; morula; ; embryo; ; spermatid; ; spermatocyte; ; testicle; ; epiblast;
	More reference expression data
	More reference expression data
Orthologs
	4113
	434903
	ENSG00000099399
	ENSMUSG00000035427
	O15479
	A2A9R3
	NM_002364
	NM_001033492
	NP_002355
	NP_001028664
	Wikidata
View/Edit Human	View/Edit Mouse

Melanoma-associated antigen B2 is a protein that in humans is encoded by the MAGEB2 gene.

This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21.