MAGI2

MAGI2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UEP, 1UEQ, 1UEW, 1UJV, 1WFV
Identifiers
Aliases	MAGI2, ACVRIP1, AIP-1, AIP1, ARIP1, MAGI-2, SSCAM, membrane associated guanylate kinase, WW and PDZ domain containing 2, NPHS15
External IDs	OMIM: 606382; MGI: 1354953; HomoloGene: 8189; GeneCards: MAGI2; OMA:MAGI2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	79,453,667 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	20,909,790 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; corpus callosum; ; Brodmann area 23; ; middle temporal gyrus; ; glomerulus; ; metanephric glomerulus; ; Brodmann area 46; ; parietal lobe; ; entorhinal cortex; ; postcentral gyrus;
	Top expressed in
	Rostral migratory stream; ; primary motor cortex; ; cingulate gyrus; ; substantia nigra; ; Region I of hippocampus proper; ; nucleus accumbens; ; globus pallidus; ; primary visual cortex; ; sciatic nerve; ; arcuate nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; SMAD binding; phosphatase binding; beta-1 adrenergic receptor binding; molecular adaptor activity; type II activin receptor binding; signaling receptor complex adaptor activity; protein binding; activin receptor binding; kinase activity;
Cellular component	late endosome; cytoplasm; synapse; cell junction; nucleus; neuron projection; postsynaptic density; membrane; dendrite; perinuclear region of cytoplasm; slit diaphragm; bicellular tight junction; plasma membrane; endosome; protein-containing complex; cell-cell junction;
Biological process	receptor clustering; negative regulation of cell population proliferation; positive regulation of neuron projection development; neuroligin clustering involved in postsynaptic membrane assembly; signal transduction; negative regulation of activin receptor signaling pathway; nerve growth factor signaling pathway; planar cell polarity pathway involved in axis elongation; SMAD protein signal transduction; positive regulation of receptor internalization; protein heterooligomerization; negative regulation of protein kinase B signaling; nervous system development; glomerular visceral epithelial cell development; positive regulation of synaptic vesicle clustering; cellular response to nerve growth factor stimulus; positive regulation of phosphoprotein phosphatase activity; negative regulation of cell migration; positive regulation of signal transduction; phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	9863
	50791
	ENSG00000187391
	ENSMUSG00000040003
	Q86UL8
	Q9WVQ1
	NM_001301128; NM_012301
	NM_001170745; NM_001170746; NM_015823
	NP_001288057; NP_036433
	NP_001164216; NP_001164217; NP_056638
	Wikidata
View/Edit Human	View/Edit Mouse

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 also known as membrane-associated guanylate kinase inverted 2 (MAGI-2) and atrophin-1-interacting protein 1 (AIP-1) is an enzyme that in humans is encoded by the MAGI2 gene.