MAN1A1

MAN1A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1NXC
Identifiers
Aliases	MAN1A1, HUMM3, HUMM9, MAN9, mannosidase alpha class 1A member 1
External IDs	OMIM: 604344; MGI: 104677; HomoloGene: 4316; GeneCards: MAN1A1; OMA:MAN1A1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	119,349,761 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	53,952,705 bp
RNA expression pattern
	Top expressed in
	synovial joint; ; renal medulla; ; pericardium; ; jejunal mucosa; ; lower lobe of lung; ; urethra; ; parotid gland; ; palpebral conjunctiva; ; Achilles tendon; ; skin of hip;
	Top expressed in
	parotid gland; ; mesenteric lymph nodes; ; lateral septal nucleus; ; vestibular membrane of cochlear duct; ; retinal pigment epithelium; ; lacrimal gland; ; epithelium of stomach; ; otic placode; ; submandibular gland; ; spleen;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; hydrolase activity; mannosidase activity; hydrolase activity, acting on glycosyl bonds; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; catalytic activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; extracellular exosome; endoplasmic reticulum; membrane; endoplasmic reticulum-Golgi intermediate compartment; cytosol;
Biological process	protein glycosylation; N-glycan processing; metabolism; Golgi apparatus mannose trimming;
	Sources:Amigo / QuickGO
Orthologs
	4121
	17155
	ENSG00000111885
	ENSMUSG00000003746
	P33908
	P45700
	NM_005907
	NM_008548
	NP_005898
	NP_032574
	Wikidata
View/Edit Human	View/Edit Mouse

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA is an enzyme that in humans is encoded by the MAN1A1 gene.

This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the removal of 3 distinct mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases.