MAP3K10

MAP3K10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RF0
Identifiers
Aliases	MAP3K10, MEKK10, MLK2, MST, mitogen-activated protein kinase kinase kinase 10
External IDs	OMIM: 600137; MGI: 1346879; HomoloGene: 1834; GeneCards: MAP3K10; OMA:MAP3K10 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	40,215,575 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	27,374,023 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; Amygdala; ; beta cell; ; nucleus accumbens; ; putamen; ; Brodmann area 9; ; right hemisphere of cerebellum;
	Top expressed in
	superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; muscle of thigh; ; ventricular zone; ; neural layer of retina; ; cerebellar cortex; ; spermatocyte; ; ganglionic eminence; ; ascending aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; protein homodimerization activity; transcription corepressor activity; kinase activity; protein serine/threonine kinase activity; bHLH transcription factor binding; ATP binding; MAP kinase kinase kinase activity; JUN kinase kinase kinase activity;
Cellular component	cytoplasm; intracellular anatomical structure;
Biological process	phosphorylation; positive regulation of JUN kinase activity; cell death; positive regulation of JNK cascade; negative regulation of DNA-binding transcription factor activity; protein phosphorylation; JNK cascade; peptidyl-serine phosphorylation; protein autophosphorylation; smoothened signaling pathway; peptidyl-threonine phosphorylation; negative regulation of transcription, DNA-templated; signal transduction; apoptotic process; positive regulation of apoptotic process; MAPK cascade;
	Sources:Amigo / QuickGO
Orthologs
	4294
	269881
	ENSG00000130758
	ENSMUSG00000040390
	Q02779
	Q66L42
	NM_002446
	NM_001081292; NM_001290528
	NP_002437
	NP_001277457
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase kinase kinase 10 is an enzyme that in humans is encoded by the MAP3K10 gene.