MAP3K11

MAP3K11
Identifiers
Aliases	MAP3K11, MEKK11, MLK-3, MLK3, PTK1, SPRK, mitogen-activated protein kinase kinase kinase 11
External IDs	OMIM: 600050; MGI: 1346880; HomoloGene: 37618; GeneCards: MAP3K11; OMA:MAP3K11 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	65,615,382 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,752,893 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; granulocyte; ; apex of heart; ; mucosa of transverse colon; ; right lobe of liver; ; monocyte; ; right lung; ; spleen; ; C1 segment; ; upper lobe of left lung;
	Top expressed in
	granulocyte; ; yolk sac; ; lip; ; external carotid artery; ; internal carotid artery; ; intestinal villus; ; right kidney; ; thymus; ; crypt of lieberkuhn of small intestine; ; zygote;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein homodimerization activity; mitogen-activated protein kinase kinase kinase binding; kinase activity; protein binding; identical protein binding; mitogen-activated protein kinase kinase binding; ATP binding; MAP kinase kinase kinase activity; protein serine/threonine kinase activity; protein kinase activity; JUN kinase kinase kinase activity; protein tyrosine kinase activity;
Cellular component	centrosome; membrane; microtubule organizing center; microtubule; cytoskeleton; cytoplasm; intracellular anatomical structure;
Biological process	phosphorylation; positive regulation of JUN kinase activity; cell death; positive regulation of JNK cascade; positive regulation of neuron apoptotic process; microtubule-based process; cell population proliferation; protein autophosphorylation; JNK cascade; protein phosphorylation; positive regulation of apoptotic process; MAPK cascade; peptidyl-tyrosine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	4296
	26403
	ENSG00000173327
	ENSMUSG00000004054
	Q16584
	Q80XI6
	NM_002419
	NM_022012
	NP_002410; NP_002410.1
	NP_071295
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase kinase kinase 11 is an enzyme that in humans is encoded by the MAP3K11 gene.