MAP3K14

MAP3K14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DN5, 4G3D, 4IDT, 4IDV
Identifiers
Aliases	MAP3K14, FTDCR1B, HS, HSNIK, NIK, mitogen-activated protein kinase kinase kinase 14
External IDs	OMIM: 604655; MGI: 1858204; HomoloGene: 2940; GeneCards: MAP3K14; OMA:MAP3K14 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	45,317,029 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	103,158,298 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; gastrocnemius muscle; ; muscle layer of sigmoid colon; ; apex of heart; ; gastric mucosa; ; lymph node; ; tibialis anterior muscle; ; spleen; ; right auricle of heart; ; anterior pituitary;
	Top expressed in
	granulocyte; ; lumbar spinal ganglion; ; gastrula; ; submandibular gland; ; blood; ; mesenteric lymph nodes; ; muscle of thigh; ; thymus; ; spleen; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; NF-kappaB-inducing kinase activity; protein binding; MAP kinase kinase kinase activity; ATP binding; kinase activity; protein serine/threonine kinase activity;
Cellular component	cytoplasm; fibrillar center; nucleus; cytosol; intracellular membrane-bounded organelle;
Biological process	phosphorylation; tumor necrosis factor-mediated signaling pathway; MAPK cascade; protein phosphorylation; cellular response to mechanical stimulus; immune response; positive regulation of I-kappaB kinase/NF-kappaB signaling; I-kappaB kinase/NF-kappaB signaling; NIK/NF-kappaB signaling; regulation of mitotic cell cycle; signal transduction; stress-activated protein kinase signaling cascade; activation of protein kinase activity; regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	9020
	53859
	ENSG00000006062; ENSG00000282637
	ENSMUSG00000020941
	Q99558
	Q9WUL6
	NM_003954
	NM_016896
	NP_003945
	NP_058592
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase kinase kinase 14 (MAP3K14), also known as NF-kappa-B-inducing kinase (NIK), is a MAP kinase kinase kinase enzyme that in humans is encoded by the MAP3K14 gene.