MAP3K3

MAP3K3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2C60, 2JRH, 2PPH, 4Y5O, 4YL6, 2O2V
Identifiers
Aliases	MAP3K3, MAPKKK3, MEKK3, mitogen-activated protein kinase kinase kinase 3
External IDs	OMIM: 602539; MGI: 1346874; HomoloGene: 69110; GeneCards: MAP3K3; OMA:MAP3K3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	63,696,305 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	106,046,272 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; gastric mucosa; ; apex of heart; ; right lung; ; right coronary artery; ; popliteal artery; ; tibial arteries; ; spleen;
	Top expressed in
	granulocyte; ; internal carotid artery; ; ascending aorta; ; aortic valve; ; external carotid artery; ; fossa; ; Rostral migratory stream; ; condyle; ; tunica media of zone of aorta; ; blood;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ATP binding; protein kinase activity; protein binding; MAP kinase kinase kinase activity; kinase activity; metal ion binding; nucleotide binding; transferase activity; protein serine/threonine kinase activity;
Cellular component	cytosol; cytoplasm;
Biological process	intracellular signal transduction; protein phosphorylation; positive regulation of p38MAPK cascade; protein autophosphorylation; blood vessel development; phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of mitotic cell cycle; stress-activated protein kinase signaling cascade; activation of protein kinase activity; regulation of apoptotic process; MAPK cascade; interleukin-1-mediated signaling pathway; positive regulation of cell proliferation in bone marrow; positive regulation of cell migration involved in sprouting angiogenesis; negative regulation of cellular senescence; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	4215
	26406
	ENSG00000198909
	ENSMUSG00000020700
	Q99759
	Q61084
	NM_002401; NM_203351; NM_001330431; NM_001363768
	NM_011947
	NP_001317360; NP_002392; NP_976226; NP_001350697
	NP_036077
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase kinase kinase 3 is an enzyme that in humans is encoded by the MAP3K3 gene, which is located on the long arm of chromosome 17 (17q23.3).