MAP3K7

MAP3K7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EVA, 2YIY, 4GS6, 4L3P, 4L52, 4L53, 4O91, 5JGD, 5JGA
Identifiers
Aliases	MAP3K7, MEKK7, TAK1, TGF1a, mitogen-activated protein kinase kinase kinase 7, FMD2, CSCF
External IDs	OMIM: 602614; MGI: 1346877; HomoloGene: 135715; GeneCards: MAP3K7; OMA:MAP3K7 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	90,587,072 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	32,023,467 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; corpus epididymis; ; internal globus pallidus; ; stromal cell of endometrium; ; tail of epididymis; ; caput epididymis; ; ganglionic eminence; ; corpus callosum; ; Brodmann area 23; ; Achilles tendon;
	Top expressed in
	genital tubercle; ; tail of embryo; ; Paneth cell; ; molar; ; aortic valve; ; ventricular zone; ; maxillary prominence; ; somite; ; vastus lateralis muscle; ; mandibular prominence;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; scaffold protein binding; metal ion binding; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; magnesium ion binding; MAP kinase kinase kinase activity; identical protein binding; receptor tyrosine kinase binding;
Cellular component	cytosol; membrane; plasma membrane; endosome membrane; nucleus; IkappaB kinase complex; cytoplasm;
Biological process	regulation of transcription, DNA-templated; phosphorylation; positive regulation of JUN kinase activity; stimulatory C-type lectin receptor signaling pathway; activation of NF-kappaB-inducing kinase activity; I-kappaB phosphorylation; MyD88-dependent toll-like receptor signaling pathway; transcription, DNA-templated; Fc-epsilon receptor signaling pathway; protein phosphorylation; JNK cascade; positive regulation of T cell activation; positive regulation of NF-kappaB transcription factor activity; positive regulation of interleukin-2 production; positive regulation of T cell cytokine production; histone H3 acetylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; I-kappaB kinase/NF-kappaB signaling; transforming growth factor beta receptor signaling pathway; T cell receptor signaling pathway; nucleotide-binding oligomerization domain containing signaling pathway; signal transduction; apoptotic process; Wnt signaling pathway, calcium modulating pathway; stress-activated MAPK cascade; positive regulation of macroautophagy; protein deubiquitination; anoikis; MyD88-independent toll-like receptor signaling pathway; viral process; interleukin-1-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6885
	26409
	ENSG00000135341
	ENSMUSG00000028284
	O43318
	Q62073
	NM_003188; NM_145331; NM_145332; NM_145333
	NM_009316; NM_172688
	NP_003179; NP_663304; NP_663305; NP_663306
	NP_033342; NP_766276
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), also known as TAK1, is an enzyme that in humans is encoded by the MAP3K7 gene.