MAP4K4

MAP4K4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4OBO, 4OBP, 4OBQ, 4RVT, 4U43, 4U44, 4U45, 4ZK5, 4U42, 5DI1, 4U3Y, 4U3Z, 4U41, 4U40
Identifiers
Aliases	MAP4K4, FLH21957, HEL-S-31, HGK, MEKKK4, NIK, mitogen-activated protein kinase kinase kinase kinase 4
External IDs	OMIM: 604666; MGI: 1349394; HomoloGene: 7442; GeneCards: MAP4K4; OMA:MAP4K4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	101,894,689 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	40,026,310 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; ganglionic eminence; ; corpus callosum; ; internal globus pallidus; ; dorsal motor nucleus of vagus nerve; ; sural nerve; ; inferior olivary nucleus; ; ventricular zone; ; external globus pallidus; ; Amygdala;
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; tail of embryo; ; genital tubercle; ; granulocyte; ; sciatic nerve; ; utricle; ; superior cervical ganglion; ; Rostral migratory stream; ; otic vesicle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; creatine kinase activity; protein serine/threonine kinase activity; nucleotide binding; protein kinase activity; protein binding; ATP binding; kinase activity; MAP kinase kinase kinase kinase activity; microtubule binding;
Cellular component	cytoplasm; focal adhesion;
Biological process	protein phosphorylation; regulation of JNK cascade; intracellular signal transduction; negative regulation of apoptotic process; microvillus assembly; phosphorylation; MAPK cascade; regulation of mitotic cell cycle; neuron projection morphogenesis; negative regulation of neuron projection development; negative regulation of insulin secretion involved in cellular response to glucose stimulus; negative regulation of neuron projection regeneration; negative regulation of cell-matrix adhesion; signal transduction; positive regulation of cell migration; stress-activated protein kinase signaling cascade; positive regulation of ARF protein signal transduction; activation of protein kinase activity; positive regulation of GTPase activity; positive regulation of keratinocyte migration; positive regulation of focal adhesion assembly; positive regulation of adherens junction organization;
	Sources:Amigo / QuickGO
Orthologs
	9448
	26921
	ENSG00000071054
	ENSMUSG00000026074
	O95819
	P97820
	NM_001242559; NM_001242560; NM_004834; NM_145686; NM_145687
	NM_001252200; NM_001252201; NM_001252202; NM_008696
	NP_001229488; NP_001229489; NP_004825; NP_663719; NP_663720
	NP_001239129; NP_001239130; NP_001239131; NP_032722
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) – also known as hepatocyte progenitor kinase-like/germinal center kinase-like kinase (HGK) and Nck-interacting kinase (NIK) – is an enzyme, specifically a serine/threonine (S/T) kinase encoded by the MAP4K4 gene in humans.

MAP4K4 is involved in a wide array of physiological processes including cell migration, proliferation and adhesion; its activity has been implicated in systemic inflammation, metabolic disorders, cardiovascular disease and cancer.

While MAP4K4 has been found to be upregulated in a wide array of cancers, there is currently limited information regarding its specific involvement. However, there is increasing evidence that suggests MAP4K4 has an important role in the development and progression of cancer, and may serve as a novel target for cancer therapeutics.