MAPK4

MAPK4
Identifiers
Aliases	MAPK4, ERK-4, ERK4, PRKM4, p63-MAPK, p63MAPK, mitogen-activated protein kinase 4
External IDs	OMIM: 176949; MGI: 2444559; HomoloGene: 2058; GeneCards: MAPK4; OMA:MAPK4 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	50,731,826 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	74,065,359 bp
RNA expression pattern
	Top expressed in
	caudate nucleus; ; nucleus accumbens; ; right frontal lobe; ; anterior cingulate cortex; ; putamen; ; right adrenal cortex; ; right hemisphere of cerebellum; ; left adrenal cortex; ; Amygdala; ; prefrontal cortex;
	Top expressed in
	olfactory tubercle; ; habenula; ; visual cortex; ; Epithelium of choroid plexus; ; superior frontal gyrus; ; primary visual cortex; ; primary motor cortex; ; prefrontal cortex; ; globus pallidus; ; cingulate gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein serine/threonine kinase activity; ATP binding; kinase activity; protein heterodimerization activity; nucleotide binding; protein kinase binding; protein homodimerization activity; protein kinase activity; transferase activity; protein binding; MAP kinase activity;
Cellular component	cytosol; nucleoplasm; nucleus; cytoplasm;
Biological process	protein phosphorylation; cell cycle; phosphorylation; MAPK cascade; regulation of gene expression; cellular response to organic substance; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	5596
	225724
	ENSG00000141639; ENSG00000282110
	ENSMUSG00000024558
	P31152
	Q6P5G0
	NM_001292039; NM_001292040; NM_002747
	NM_172632; NM_001360936
	NP_001278968; NP_001278969; NP_002738
	NP_766220; NP_001347865
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase 4 is an enzyme that in humans is encoded by the MAPK4 gene.

Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets.

The Arabidopsis MAPK4 is important in signalling

Mechanistically, MAPK4 directly bound and activated AKT by phosphorylation of the activation loop at threonine 308. It also activated mTORC2 to phosphorylate AKT at serine 473 for full activation. MAPK4 overexpression induced oncogenic outcomes, including transforming prostate epithelial cells into anchorage-independent growth, and MAPK4 knockdown inhibited cancer cell proliferation, anchorage-independent growth, and xenograft growth.