| MAPK8IP3 |
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| Identifiers |
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| Aliases | MAPK8IP3, JIP3, JSAP1, SYD2, syd, JIP-3, mitogen-activated protein kinase 8 interacting protein 3 |
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| External IDs | OMIM: 605431; MGI: 1353598; HomoloGene: 22790; GeneCards: MAPK8IP3; OMA:MAPK8IP3 - orthologs |
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| Gene location (Mouse) |
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| | Chr. | Chromosome 17 (mouse) |
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| | Band | 17 A3.3|17 12.53 cM | Start | 25,111,127 bp |
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| End | 25,155,951 bp |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - right hemisphere of cerebellum
- right frontal lobe
- anterior pituitary
- prefrontal cortex
- granulocyte
- sural nerve
- cingulate gyrus
- left ovary
- anterior cingulate cortex
- right ovary
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| | Top expressed in | - dentate gyrus of hippocampal formation granule cell
- superior frontal gyrus
- neural layer of retina
- primary visual cortex
- perirhinal cortex
- entorhinal cortex
- central gray substance of midbrain
- cerebellar cortex
- superior colliculus
- CA3 field
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| | More reference expression data |
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| BioGPS | |
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| Wikidata |
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C-jun-amino-terminal kinase-interacting protein 3 is an enzyme that in humans is encoded by the MAPK8IP3 gene.
The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport, possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
